Ubiquinone and ubiquinol are both compounds derived from CoQ10, or coenzyme Q10, which is an antioxidant often utilized in supplement form to boost whole body health, improve fertility, and support cardiovascular health. Both forms have the same functions in the body. Based on research, the main difference between the two compounds is that ubiquinol is claimed to be more bioavailable than ubiquinone, which means it can be better absorbed by the body.
- The typical dose of ubiquinol is around 200 mg. That said, there are certain conditions that require a higher dose – generally ranging between 300 mg to 600 mg. Studies have shown that 600 mg of ubiquinol is the optimal dose for fertility in both men and women. In men, this dose increases the concentration, motility, and density of sperm in men experiencing infertility. In women, this dose improves fertility by activating a natural ovarian response and lessens the effects of aging on ovaries.
- Safarinejad, M. R., Safarinejad, S., Shafiei, N., & Safarinejad, S. (2012). Effects of the reduced form of coenzyme Q10 (ubiquinol) on semen parameters in men with idiopathic infertility: a double-blind, placebo controlled, randomized study. The Journal of urology, 188(2), 526–531.
- Özcan, P., Fıçıcıoğlu, C., Kizilkale, O., Yesiladali, M., Tok, O. E., Ozkan, F., & Esrefoglu, M. (2016). Can Coenzyme Q10 supplementation protect the ovarian reserve against oxidative damage?. Journal of assisted reproduction and genetics, 33(9), 1223–1230.
- Xu, Y., Nisenblat, V., Lu, C., Li, R., Qiao, J., Zhen, X., & Wang, S. (2018). Pretreatment with coenzyme Q10 improves ovarian response and embryo quality in low-prognosis young women with decreased ovarian reserve: a randomized controlled trial. Reproductive biology and endocrinology : RB&E, 16(1), 29.